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  • Physician-Led
  • RN-Monitored
  • Private NY Clinics

Antidepressants Not Working? Ketamine for Depression in New York

Ketamine offers a safe, fast-acting alternative that can shift mood, thought patterns, and emotional presence in days, not weeks.

  • 1–4 Hrs

    First Mood Shift For Many Patients

  • 2,500+

    Patients treated since 2020

  • RN-Monitored

    Your Own Nurse, Start To Finish

  • From $550

    $200 Less Than Many NY Clinics

Understanding Treatment- Resistant Depression

An estimated 21 million U.S. adults had at least one major depressive episode in 2021, and for many, traditional medications don’t work.

 After several medications that haven’t helped, many people begin to feel hopeless, numb, or disconnected from themselves.

Ketamine Offers Another Path

1

You try an antidepressant.

2

You wait 6–12 weeks.

3

It doesn’t work–or only helps a little.

4

Your doctor switches medications.

5

You wait another 6–12 weeks.

6

Side effects get worse.

7

You’re told to “try one more.”

1

You try an antidepressant.

""

2

You wait 6–12 weeks.

""

3

It doesn’t work — or only helps a little.

""

4

Your doctor switches medications.

""

5

You wait another 6–12 weeks.

""

6

Side effects get worse.

""

7

You’re told to “try one more.”

""

 After several medications that haven’t helped, many people begin to feel hopeless, numb, or disconnected from themselves.

Ketamine Offers Another Path

Is IV Ketamine Right For You?

  • A Good Fit If You

    • Tried 2+ Antidepressants Without Relief
    • Live With Treatment-Resistant Depression
    • Had Tough Side Effects From Medications
  • Not Recommended With

    • Psychosis Or Active Schizophrenia
    • Uncontrolled High Blood Pressure
    • Active Substance Use Disorder
    • Certain Heart Conditions

Dr. Pervaiz Qureshi, MD Depending on circumstances. Dr. Qureshi confirms fit at your consultation.

Why Ketamine Helps When Antidepressants Don’t

Ketamine infusion therapy in New York works differently from SSRIs and SNRIs. Instead of slowly adjusting neurotransmitters like serotonin, ketamine acts on the brain’s glutamate system.

  • Acts on Glutamate

    Ketamine blocks some glutamate signals, which helps brain cells build new connections.

  • Rapidly reduces rumination

    Many patients describe it as “quieting” the critical internal voice.

  • Improves emotional presence

    Patients feel more like themselves again, not numb or flat.

  • Works within hours, not weeks

    Many patients notice a first mood shift within 1 to 4 hours.

Symptoms Ketamine Can Help Improve

Even if you’ve had multiple failed antidepressants, ketamine may still be effective.

IV Ketamine, Spravato, or At‑Home Ketamine?

  • Our treatment

    IV Ketamine

    • Full dose reaches your bloodstream
    • Physician-approved, nurse-monitored
    • Cash-pay with superbill
  • Spravato Nasal Spray

    • FDA-approved for treatment-resistant depression
    • 2-hour observation in clinic
    • Often insurance-covered (not offered here)
  • At-Home Ketamine

    • Lozenges or tablets
    • Only part of the dose absorbed
    • No in-person monitoring

Want insurance coverage first? Ask your insurer about Spravato. Want physician-dosed, fully monitored care? That’s all we do.

What the Research Says

Clinically Studied Outcomes Showing Real-World Improvement

  • About 45% responded in real-world studies of 2,665 patients with treatment-resistant depression (2022 review)
  • Some people notice improvement within hours, but the effect can fade within days or weeks
  • The benefit did not significantly decline with repeated treatments
  • Ketamine works on a different brain system than typical antidepressants
  • Used alongside psychotherapy, it may strengthen and extend the benefits

Your Depression Treatment Protocol

Intake Form and Free Phone Consultation

Fill out a short intake form, then talk with our doctor by phone, free. We review your mental health history, medications and goals. No referral or lab work needed.

Your Infusions

About 45 minutes each, some up to an hour, with your own registered nurse, then about 60 minutes of recovery. Your plan depends on you; some patients start with 2 to 3 infusions a week, then space them out as they improve.

Optional Integration Therapy

Referrals to trusted integration therapists. With your consent, we also coordinate with your own therapist or psychiatrist.

Booster Treatments

No fixed schedule. Our physician sets the timing with you, based on how you respond.

Plan about 2 hours for your first visit. Don’t eat or drink for 4 hours beforehand. Someone needs to drive you home, and you shouldn’t drive for 24 hours.

Safety & Monitoring

Board-certified physician Dr. Pervaiz Qureshi, MD reviews and approves every patient’s treatment, and a registered nurse monitors you throughout every infusion.

Continuous RN monitoring

Dedicated nurse present throughout your entire session

Vital signs tracking

Your nurse tracks your vital signs from IV placement to discharge.

Controlled dosing

Our physician approves your treatment, and your nurse can slow or pause the infusion at any time.

ER-experienced nurses

Our nurses have emergency-room experience, and emergency equipment is on site.

Calm environment

Calm, supportive treatment environment

Pricing for IV Ketamine Depression Treatment

  • Same price at both clinics · Cash-pay · HSA/FSA accepted
  • Itemized superbill for out-of-network claims · Financing through CareCredit
  • We don’t bill Medicaid, Medicare, or insurers directly

Where We Treat Depression in New York

  • Long Island (Great Neck)

    By Appointment
    • 45 Middle Neck Rd, Suite #22A  Great Neck, NY 11021
      Open 7 days
    • (516) 445-7191
    • Serving Nassau County, Western Long Island, and Eastern Queens.
    See the Long Island Clinic
  • Queens (Jackson Heights)

    Open 7 Days
    • 37-20 76th St, Suite #100  Jackson Heights, NY 11372
    • (516) 203-1041
    • Serving Queens, Manhattan, Brooklyn, and the Bronx.
    See the Queens Clinic

Same protocol, same price, same medical team. Open 7 days.

What A Patient Says

I struggled with depression, anxiety, and PTSD for years. I’d tried CBT, DBT, EMDR, Lithium, Abilify, and more before finding relief here. Since starting ketamine, I feel so much better, the pain in my body eased, and I feel more positive and safe. That’s a huge success for me.

Ivonne F., Google review

Frequently Asked Questions

How quickly will I feel relief?

Some people notice improvement within hours, but the effect can fade within days or weeks, which is why treatment is usually a series. Everyone responds differently.

Yes. Ketamine is studied for treatment-resistant depression. In a 2022 review of real-world studies of 2,665 patients, about 45% responded. It helps many people, but not everyone.

In a medical setting, the risk of dependence is considered very low. Every dose is given in our clinic under nurse monitoring, and nothing goes home with you.

If you’re in danger right now, call 988 or 911. Ketamine may ease suicidal thinking within hours or days for some people. Tell us at your consultation so we can plan your care safely.

No. Keep taking your medications, and never stop or change one on your own. Our doctor reviews every medication first. Research suggests higher doses of benzodiazepines may weaken ketamine’s effect on the first day after an infusion.

Many people describe a dream-like or floating feeling. You stay fully aware of where you are, and the feeling is temporary. Your own registered nurse stays with you and can slow or pause the infusion.

It varies. Ketamine’s effect can fade within days or weeks, which is why treatment is usually a series. Boosters have no fixed schedule; our physician sets them with you based on how you respond. Learn more about how long ketamine lasts for depression.

Not everyone responds. Our physician reviews how you respond and adjusts your plan with you, and we talk openly about other options.

IV ketamine is cash-pay. Your first session is $550, a single infusion is $650, and a package of 6 is $3,250, which doesn’t expire. We provide a superbill for out-of-network claims, accept HSA and FSA, and offer financing through CareCredit. We don’t bill Medicaid or Medicare.

 No. Someone needs to drive you home, and you shouldn’t drive for 24 hours after an infusion.

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